Views:13 Author:Site Editor Publish Time: 2018-10-12 Origin:Site
The acute toxicity of cinnamaldehyde is relatively low, with LD50 values ranging from 0.6 to more than 2 g/kg in various species. The LD50 of cinnamaldehyde in white rats, white mongrel mice and guinea pigs was reported as 3.4 g/kg. The LD50 of cinnamic aldehyde in mice by the ip route was reported as 2.318 g/kg. The acute dermal LD50 in rabbits was reported as 0.59 ml/kg by Shelanski. Cinnamaldehyde in toothpaste could be the reason for allergic contact dermatitis and allergic contact stomatitis.
North American Contact Dermatitis Research Group suggested that cinnamaldehyde might be a frequent cause of allergic reactions to perfumes Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities of renal, serum and urinary enzymes.
CNMA-induced glucosuria in these rats was accompanied by marked proteinuria and creatinuria. Increased serum blood urea nitrogen and serum creatinine and decreased serum protein and glucose levels were observed in these rats. Thus, CNMA at the dose of 73.5mg/kg body weight/day for 90 days exert its effect on kidney of male albino wistar rat and its effect is time and dose dependent.