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Methyl cinnamate inhibits tyrosinase catalytic reaction

Views:11     Author:Site Editor     Publish Time: 2019-03-21      Origin:Site

Whether it is stain or dark skin, it is related to melanin. The melanin bodies in melanocytes contain melanin and are therefore black. Analysis of the superficial stratum corneum of the yellow exposed area and the non-exposed area revealed that the skin surface of the exposed area contained more melanin, which proved that sunlight was related to darkening of the skin. More specifically, ultraviolet rays in sunlight darken the skin. When ultraviolet light (usually UVA and UVB reaching the surface) is irradiated onto the skin, it will cause a large amount of free radicals, inflammatory factor release, collagen damage and even DNA breakage.

Methyl cinnamate


Compared with the normal area with even skin tone, the melanocytes in the pigmented area are more active, and the source continuously supplies melanin from the bottom of the epidermis, resulting in persistent pigment accumulation. For the same reason as blackening, the stains are also aggravated by sunlight.


The study further proves that the inhibition of the enzyme by methyl cinnamate is a reversible process. Methyl cinnamate reduces the catalytic efficiency by inhibiting the enzymatic activity, rather than decreasing the enzyme activity by reducing the amount of effective enzyme. This also suggests that the combination of methyl cinnamate and the enzyme results in the inhibition of the enzyme activity, rather than inactivating the enzyme's molecular conformation permanently.


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