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High concentration of methyl cinnamate can inhibit monophenol efficiently.
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High concentration of methyl cinnamate can inhibit monophenol efficiently.

Views:10     Author:Site Editor     Publish Time: 2019-03-26      Origin:Site

Tyrosinase, also known as polyphenol oxidase, is widely found in plants, animals and humans. It is a key enzyme in the synthesis of melanin by organisms. Tyrosinase inhibitors inhibit melanin production by inhibiting tyrosinase activity, and thus can be used to prevent and treat diseases such as pigmentation and melanoma. At present, tyrosinase inhibitors such as hydroquinone, fruit acid, vitamin C, kojic acid, and arbutin have been used as a whitening agent in cosmetics, but hydroquinone and fruit acids have gradually been eliminated due to irritation; vitamin C Kojic acid is easily oxidized and has a short shelf life.

methyl cinnamate


Arbutin is widely used as a plant extract because it has the advantages of safe action. However, the inhibitory effect of tyrosinase is not strong. The amount of arbutin added in cosmetics should be as high as 2% to be effective. Therefore, the development of safe and efficient tyrosinase inhibitors has attracted more and more attention from methyl cinnamate suppliers.


Hysteresis is a typical feature of tyrosinase catalyzed oxidation of L2 tyrosine. The study found that when the concentration of methyl cinnamate was 0.80 mmol/L, the delay time was extended to 3.2 min, and the hysteresis time was increased by nearly 3 times. The relative inhibition rate of methyl cinnamate against monophenols increased with the increase of methyl cinnamate concentration, resulting in a methyl cinnamate concentration (IC50) of approximately 0.61 when the relative inhibition rate of monophenolic enzyme reached 50%. The concentration of methyl cinnamate (IC50), which caused the relative inhibition rate of diphenolase to reach 50%, was approximately 1.49 mmol/L.


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