Views: 6 Author: Site Editor Publish Time: 2018-10-12 Origin: Site
The human brain is a very intricate system and several factors such as age and various diseases may affect its working. Diabetes mellitus (DM) is a metabolic disease that can have worsening effects on many organs, including the brain. It adversely affects the central nervous system leading to cognitive impairments. Although both diabetes types play a crucial role in memory weakening, their mode of action on memory and learning system remains unclear.
It is reported that factors such as improved apoptosis, reduced neuronal densities, metabolic impairments, and oxidative stress are crucial in the pathogenesis of cognitive impairment and memory deficiency. Several studies recommended a significant role of oxidative stress in the pathogenesis of cognitive impairment.
The long-term hyperglycemia enhances glucose oxidation, which sequentially produces reactive oxygen species (ROS) causing increased oxidative stress; this leads to morphological and functional changes in the hippocampus due to the excessive production of malanoldehyde (MDA) and reduced efficacy of superoxide dismutase (SOD). Moreover, cinnamic acid supplier said that dietary enrichment with nutritional antioxidants could improve the cognitive function not only in normal subjects but also in cognitive deficits after stroke.
Although many antioxidants are available, we used a natural approach to suppress the oxidative stress in the brain. Cinnamon (Cinnamomum cassia) is widely used for centuries as a natural spice and flavoring material throughout the world. In some countries, it is used in traditional medicine as an antidiabetic agent. Cinnamon contains volatile oils such as cinnamaldehyde, eugenol, and cinnamic acid; phenolic compounds such as tannin, catechins, and proanthocyanidin; mono terpenes and sesquiterpenes; and trace coumarin.